Figure 9.

Conditional association analysis reveals common association pattern for PRSS2 pancreas eQTLs and meconium ileus risk

GTEx v8 variant calls lifted to KI270803.1 and deletion allele (red diamond) imputed from 10XG calls.

(A)Recalculated PRSS2 pancreas eQTLs.

(B)GTEx PRSS2 pancreas eQTLs conditioning on deletion polymorphism.

(C)PRSS2 pancreas eQTLs conditioning on rs62473563 (orange diamond).

(D)GTEx PRSS2 pancreas eQTLs conditioning on both rs62473563 and deletion polymorphism.

(E)Association with meconium ileus was similarly performed for 309 10XG samples.

(F)Meconium ileus risk conditioning on deletion polymorphism.

(G)Meconium ileus risk conditioning on rs62473563.

(H)Meconium ileus risk conditioning on both rs62473563 and deletion polymorphism.