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. 2022 Oct 27;13:1013049. doi: 10.3389/fimmu.2022.1013049

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Copyright © 2022 Zhong, Xu, Wang, Peng, Wang, He, Liu, Ni and He

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Screening of CAPN8-related hub pathways in thyroid cancer. (A, B) Coefficient profiles (A) and deviance profiles (B) of the adaptive Least Absolute Shrinkage and Selection Operator regression model. Six cancer hallmarks were selected. (C) Error rate of the random survival forest (RSF) model. Eight cancer hallmarks were determined. (D, E) Importance (D) and marginal effect (E) of each pathway in the RSF model. The blue color represented pathways with a certain influence on overall survival, while the red color represented background noise with no impact on the dependent variable.