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. 2022 Oct 27;13:1013049. doi: 10.3389/fimmu.2022.1013049

Figure 5.

Figure 5

Different tumor immune microenvironment (TIME) patterns in the E2F-Clust and ImmClust. (A) The enrichment analysis identified five upregulated pathways in CS1 of E2F-Clust. (B) There was a significant difference in PFS among the three ImmClusters. (C) Different TIME patterns among the three ImmClusters, including the immune exhausted (CS1), inflammatory (CS2), and immune desert (CS3) subtypes. (D) The Immune Enrichment Score and the Stromal Enrichment Score differ in the three ImmClusters. (E) Different responses to immunotherapy of the three ImmClusters. OS, overall survival; PFS, progression-free survival; FDR, false discovery rate; TIME, tumor immune microenvironment.