Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Oct 27;13:1013049. doi: 10.3389/fimmu.2022.1013049

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Zhong, Xu, Wang, Peng, Wang, He, Liu, Ni and He

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Different paradigms of DNA replication stress and drug sensitivity in the E2F-Clust and ImmClust. (A) Activities of 21 pathways related to DNA replication stress in the E2F-Clust and ImmClust. There was evident downregulation of DNA replication stress in the CS3 subtype. (B) The E2F-Clust stratified patients into two groups with distinct differences in clinical TNM stages and progression-free survival. (C) IC50 (half maximal inhibitory concentration) of typical inhibitors targeting ATR and week 1 protein. Patients of CS2 showed a tendency to be drug resistant. ***P < 0.001.