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. 2022 Oct 27;13:1013049. doi: 10.3389/fimmu.2022.1013049

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Copyright © 2022 Zhong, Xu, Wang, Peng, Wang, He, Liu, Ni and He

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Application of the E2F-Clust and ImmClust in two external validation datasets (N = 78, N = 95). (A) The exhausted, inflamed, and desert TIME patterns remain recognizable after the application of E2F-Clust and ImmClust in the combined validation dataset (N = 78). (B) The exhausted, inflamed and desert TIME patterns are still distinct after applying the E2F-Clust and ImmClust in GSE27155 (N = 95). (C) CS2 still showed a tendency to be drug resistant in the combined validation dataset (N = 78). (D) Patients of CS2 are potentially resistant to common chemotherapeutics in GSE27155 (N = 95). (E) CS1 is prone to response to anti-PD-1 treatment in the combined validation dataset (N = 78). (F) Anti-PD-1 treatment is feasible in patients of CS1 subtype in GSE27155 (N = 95). *P < 0.05, ***P < 0.001.