Table 3.
Cox regression analysis of prognostic factor for gastric cancer.
Variable | Univariate Model | Reduced Multivariate Model | ||||||
---|---|---|---|---|---|---|---|---|
HR | 95%CI | p | HR | 95%CI | P | |||
Gender | 0.631 | |||||||
Female | Ref | |||||||
Male | 0.849 | 0.43 | 1.65 | 0.631 | ||||
Age (years) | 0.960 | |||||||
≤ 60 | Ref | |||||||
> 60 | 0.985 | 0.53 | 1.80 | 0.960 | ||||
BMI (kg/m2) | 0.020 | 0.156 | ||||||
≤ 25 | Ref | Ref | ||||||
> 25 | 2.078 | 1.12 | 3.85 | 0.020 | 1.579 | 0.84 | 2.97 | 0.156 |
Tumor size (cm) | 0.044 | 0.069 | ||||||
≤ 5 | Ref | Ref | ||||||
> 5 | 1.758 | 1.02 | 3.05 | 0.044 | 1.685 | 0.96 | 2.95 | 0.069 |
Tumor location | 0.121 | |||||||
Lower 1/3 | Ref | |||||||
Middle 1/3 | 1.246 | 0.56 | 2.78 | 0.590 | ||||
Upper 1/3 | 1.879 | 1.01 | 3.47 | 0.044 | ||||
Borrmann type | 0.484 | |||||||
I+ II | Ref | |||||||
III+IV | 1.293 | 0.63 | 2.66 | 0.484 | ||||
Differentiation type | 0.055 | |||||||
Undifferentiated | Ref | |||||||
Differentiated | 0.547 | 0.30 | 1.01 | 0.055 | ||||
TNM stage | 0.001 | 0.003 | ||||||
I+II | Ref | Ref | ||||||
III | 3.885 | 1.75 | 8.65 | 0.001 | 3.320 | 1.48 | 7.42 | 0.003 |
Vessel invasion | 0.903 | |||||||
Negative | Ref | |||||||
Positive | 0.965 | 0.54 | 1.71 | 0.903 | ||||
CDK5RAP3/UFM1 expression | 0.002 | 0.006 | ||||||
CDK5RAP3 low and UFM1 low | Ref | Ref | ||||||
CDK5RAP3 high and/or UFM1 high | 0.312 | 0.15 | 0.64 | 0.002 | 0.357 | 0.17 | 0.74 | 0.006 |