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. 2022 Oct 27;12:927751. doi: 10.3389/fonc.2022.927751

Table 3.

Cox regression analysis of prognostic factor for gastric cancer.

Variable Univariate Model Reduced Multivariate Model
HR 95%CI p HR 95%CI P
Gender 0.631
Female Ref
Male 0.849 0.43 1.65 0.631
Age (years) 0.960
≤ 60 Ref
> 60 0.985 0.53 1.80 0.960
BMI (kg/m2) 0.020 0.156
≤ 25 Ref Ref
> 25 2.078 1.12 3.85 0.020 1.579 0.84 2.97 0.156
Tumor size (cm) 0.044 0.069
≤ 5 Ref Ref
> 5 1.758 1.02 3.05 0.044 1.685 0.96 2.95 0.069
Tumor location 0.121
Lower 1/3 Ref
Middle 1/3 1.246 0.56 2.78 0.590
Upper 1/3 1.879 1.01 3.47 0.044
Borrmann type 0.484
I+ II Ref
III+IV 1.293 0.63 2.66 0.484
Differentiation type 0.055
Undifferentiated Ref
Differentiated 0.547 0.30 1.01 0.055
TNM stage 0.001 0.003
I+II Ref Ref
III 3.885 1.75 8.65 0.001 3.320 1.48 7.42 0.003
Vessel invasion 0.903
Negative Ref
Positive 0.965 0.54 1.71 0.903
CDK5RAP3/UFM1 expression 0.002 0.006
CDK5RAP3 low and UFM1 low Ref Ref
CDK5RAP3 high and/or UFM1 high 0.312 0.15 0.64 0.002 0.357 0.17 0.74 0.006