Figure 2.

Molecular bases of epitope–HLA-I complexes and effects of epitope mutations. Interactions between KIA_S peptide and HLA-A*02:01 (from PDB:7EU2) (A), NYN_S peptide and HLA-A*24:02 (7F4W) (B), RLQ peptide and HLA-A*02:01 (7N1B) (C), and YLQ peptide and HLA-A*02:01 (7N1A) (D). For all the structures, HLA heavy chains are green, the SARS-CoV-2 peptides are purple, and residues with predominant mutational rates with an effect on immune escape are shown in yellow. Residues at the interface of the interaction of HLA with peptides are represented: nitrogen atoms in blue, oxygen atoms in red, and hydrogen bonds are indicated by black dashed lines.