Figure 3.

Molecular bases of TCR–epitope–HLA-I complexes and effects of epitope mutations. (A) Overview of RLQ3–RLQ–HLA-A2 complex (7N1E). (B) Close-up view of interactions of T1006 (yellow), residue with predominant mutational rates in VOCs, with TCR RLQ3 and HLA-A2. (C) Overview of YLQ7–YLQ–HLA-A2 complex (7N1F). (D, E) Close-up view of interactions of T274 and L270 (yellow), with TCR YLQ7 and HLA-A2. For all the structures, HLA heavy chains are green, the SARS-CoV-2 peptides are purple, while residues with a predominant mutational rate with an effect on immune escape are shown in yellow. Residues at the interface of the interaction of HLA with peptides are represented: nitrogen atoms in blue, oxygen atoms in red, and hydrogen bonds are indicated by black dashed lines.