Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Oct 27;13:1027472. doi: 10.3389/fimmu.2022.1027472

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Wang, Xiong, Fu, Guo, Zaky, Lin and Wu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

miRNAs regulate autophagy after Mtb infection. In the process of autophagy, membrane vesicles encapsulate cytoplasm and organelles to form autophagosomes, which then fuse with lysosomes to form autophagolysosomes. After Mtb infection, miRNAs inhibit or activate autophagy process by modulating ATG genes and other autophagy factors. In this process, various miRNAs are mainly involved in the formation of autophagosomes. The host can defend against the invasion of Mtb by miRNAs. In addition, Mtb also develops strategies to combat autophagy by modulating miRNA expression. “Increase” represents the upregulation of miRNAs, “Decrease” represents the downregulation of miRNAs. “Induce” represents miRNAs promote gene expression, “Inhibit” represents miRNAs suppress gene expression , *represents miRNAs’ passenger strand.