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. 2022 Oct 27;13:1027472. doi: 10.3389/fimmu.2022.1027472

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Copyright © 2022 Wang, Xiong, Fu, Guo, Zaky, Lin and Wu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differential expression of miRNAs in TB and LTBI. Differentially expressed miRNAs were divided into eight categories (A–H). miRNAs in the a region are only upregulated in TB patients. miRNAs in the b region are reduced only in TB patients. miRNAs in the c region diminish in TB and LTBI. miRNAs in the d region are decreased in patients with LTBI. miRNAs in the e region are increased in patients with LTBI. miRNAs in the f region are elevated in LTBI but downregulated in TB. miRNAs in the g region are both increased. miRNA in the h region is higher in TB, but decreases in LTBI. miRNAs in the (C, F–H) regions should be focused on, and miRNAs in the f and h regions have higher potential for biomarkers.