Figure 3.
IL-1Ra plasma exposure (AUC0-24) from 1000 simulations, in studied populations and extrapolated to extremely premature neonates. Simulated exposure for (A) a 70 kg adult receiving 100 mg daily, (B) a 70 kg adult with severe renal impairment receiving 100 mg daily, (C) a 70 kg adolescent receiving 1 mg/kg daily, (D) a 2-year-old child weighing 12 kg and receiving 1 mg/kg daily, (E) a 12 kg 2-year-old child receiving 3 mg/kg daily. Simulations in extrapolated PK: (F) an extremely premature neonate (25-weeks GA, 850 g) with mature non-renal clearance receiving 1 mg/kg alternate daily, (G) an extremely premature neonate receiving 1.5 mg/kg daily, (H) an extremely premature neonate with 25% function of non-renal clearance receiving 1 mg/kg alternate daily, and (I) an extremely premature neonate with 25% function of non-renal clearance receiving 1.5 mg/kg daily. The dashed line indicates the threshold of 9.6 mg/l x h identified in (28) as the exposure above which sufficient suppression in auto-immune disease is achieved.