Table 2.
Published PK and population PK parameter values for anakinra.
| Reference | Population | N | Dose | Route | CL (l/h/70kg) | BSV CL (%) | VD (l/70kg) |
|---|---|---|---|---|---|---|---|
| Yang B et al. (40) | Adults | 341 | 30-150 mg | SC | 6.92 | 9.94 | |
| Yang B et al. (30) | HD PD Normal GFR |
10 10 12 |
1 mg/kg | IV | 1.09 1.15 7.3 |
9.99 (initial 2.95) 9.8 (initial 3.26) 8.86 (initial 3.32) |
|
| Yang B 2003 (30) | Stratified by GFR | 30 | 100 mg | SC | 10.2 to 2.6 | ||
| Gueorguieva et al. (41) | Adult | 6.96 | 23 | 5.14 | |||
| Urien et al. (28) | Children | 87 | 2-10 mg/kg | SC | 6.24 | 54 | 6.52 |
| Yang B et al. (38) | Adults Adults |
32 32 |
100 mg 100 mg |
IV SC |
6.72 8.04 |
8.18 |
BSV, between-subject variability; CL, clearance; GFR, glomerular filtration rate; VD, volume of distribution.