Figure 4.

Full-dose oxaliplatin induces greater immunosuppression. (A), Body weight in CT26-bearing mice before or after treatment with Rat IgG, anti-TIGIT mAbs plus various-dose OX for 2 days. (B), The counts of WBC (left), Lymph (mid) and RBC (right) in peripheral blood of CT26-bearing mice. (C), Absolute numbers of tumor-infiltrating CD45⁺ cells and CD8⁺ T cells. Each symbol represents an individual mouse. Data were representative of at least two independent experiments. Error bars represent means ± SEM. Statistical significance was determined using paired two-tailed t test (A) or one-way ANOVA followed by Tukey’s multiple-comparisons (B, C). ns, p > 0.05; *p < 0.05; **p < 0.01 and ***p < 0.001.