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. 2022 Oct 27;13:1040256. doi: 10.3389/fimmu.2022.1040256

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Copyright © 2022 Fang, Sun, Xiao, Tang, Tian, Wei, Sun and Zheng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Oxaliplatin induces immunogenic cell death of CT26 colon cancer. (A), Representative immunofluorescence staining of calreticulin (CALR) in CT26 cells after treatment with various dose OX or CIS for 4 h. Scale bar represents 10 μm. (B), Representative histogram of CALR expression on CT26 cells after treatment with various dose OX or CIS for 4 h (left). Mean fluorescent intensity (MFI) of CALR expression on CT26 were also shown (right). (C), HMGB1 concentration in the supernatants of CT26 cells treated with various dose OX or CIS for 24 h. Data were representative of at least two independent experiments. Error bars represent means ± SEM. Statistical significance was determined using unpaired two-tailed t-test (B, C). *p < 0.05; ***p < 0.001 and ****p < 0.0001. .