Figure 1.

Model of EBV infection cycle. (A) Upon primary infection through saliva, EBV infects B cells. The figure depicts a model of EBV infection, where in EBV drives naïve B cells into latency III program. This activation leads to their differentiation into latency I/O memory B cells. This is often followed by spontaneous or induced reactivation of EBV within circulating memory B cells. This figure is adapted/modified from Guo et al (44). (B) Depending on the type of latency or lytic program, EBV infected cells are associated with different malignancies.*Gastric cancer cells also express genes that are associated with latency II programs. **Post-transplant lymphoproliferative disorders express some of the genes in latency III as well.