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. 2022 Oct 27;13:1026416. doi: 10.3389/fimmu.2022.1026416

Table 1.

Characteristics of the study cohort.

HC N=76 CD_THY N=58 (29 CD, 29 THY) preT1D_LR N=85 T1D N=107
Age (years) (median - IQR) 13.8 (12.7 -14.9) 12.6 (9.8 -14.8) 12.9 (10.8 -15.5) 11.0 (9.0 -13.4)
Gender (M/F) 41/35 M=54% 16/42 M=28% 43/42 M=51% 66/41 M=62%
BMIp (median - IQR) 64.9 (22.9-77.83) 41.6 (23.7-68.3) 72.4 (30.95-82.72) 42.0 (6.4-73.1)
HbA1c (mmol/L) (median - IQR) NA NA NA 103.0 (87.0-117.0)
n. of islet Aabs 0 Aab=74/76
1 Aab=2/76
0 Aab=50/53
1 Aab=2/53
2 Aab=1/53
0 Aab=77/85
1 Aab=8/85
0 Aab=3/107
1 Aab=16/107
2 Aab=32/107
>3 Aab=56/107
Anti-TPO NA 10/11 THY
1/22 CD
NA 16/107
Anti-TG 0/59 1/7 THY
26/29 CD
2/84 15/107
HLA_DR3 and/or DR4 9/54 27/35 48/85 73/85
WBC (10x3 ul) (median - IQR) 6.1 (5.1-7.5) 6.0 (5.2-7.1) 6.5 (5.7-8.0) 5.7 (4.8-6.6)
Neutrophils (median - IQR) 3.0 (2.4-4.0) 3.1 (2.4-3.6) 3.3 (2.6-4.2) 2.3 (1.8-2.8)
Monocytes (median - IQR) 0.5 (0.4-0.6) 0.5 (0.4-0.6) 0.5 (0.5-0.62) 0.50 (0.40-0.59)
Lymphocytes (median - IQR) 2.2 (1.9-2.7) 2.2 (1.7-2.8) 2.5 (2.0-3.0) 2.6 (2.10-3.05)

Clinical and laboratory characteristics of healthy controls (HC), subjects with celiac or thyroid diseases (CD_THY), relatives of T1D patients with 0-1 autoantibodies (preT1D_LR), and subjects with type 1 diabetes (T1D). WBC, Neutrophils, Lymphocytes, Monocytes are expressed as 10x3/ul. BMIp, Body Mass Index for age percentile; Aabs, Autoantibodies; TPO, Thyroid peroxidase; TG, Transglutaminase; WBC, White blood cells; NA, not available.