Table 1.
HC N=76 | CD_THY N=58 (29 CD, 29 THY) | preT1D_LR N=85 | T1D N=107 | |
---|---|---|---|---|
Age (years) (median - IQR) | 13.8 (12.7 -14.9) | 12.6 (9.8 -14.8) | 12.9 (10.8 -15.5) | 11.0 (9.0 -13.4) |
Gender (M/F) | 41/35 M=54% | 16/42 M=28% | 43/42 M=51% | 66/41 M=62% |
BMIp (median - IQR) | 64.9 (22.9-77.83) | 41.6 (23.7-68.3) | 72.4 (30.95-82.72) | 42.0 (6.4-73.1) |
HbA1c (mmol/L) (median - IQR) | NA | NA | NA | 103.0 (87.0-117.0) |
n. of islet Aabs | 0 Aab=74/76 1 Aab=2/76 |
0 Aab=50/53 1 Aab=2/53 2 Aab=1/53 |
0 Aab=77/85 1 Aab=8/85 |
0 Aab=3/107 1 Aab=16/107 2 Aab=32/107 >3 Aab=56/107 |
Anti-TPO | NA | 10/11 THY 1/22 CD |
NA | 16/107 |
Anti-TG | 0/59 | 1/7 THY 26/29 CD |
2/84 | 15/107 |
HLA_DR3 and/or DR4 | 9/54 | 27/35 | 48/85 | 73/85 |
WBC (10x3 ul) (median - IQR) | 6.1 (5.1-7.5) | 6.0 (5.2-7.1) | 6.5 (5.7-8.0) | 5.7 (4.8-6.6) |
Neutrophils (median - IQR) | 3.0 (2.4-4.0) | 3.1 (2.4-3.6) | 3.3 (2.6-4.2) | 2.3 (1.8-2.8) |
Monocytes (median - IQR) | 0.5 (0.4-0.6) | 0.5 (0.4-0.6) | 0.5 (0.5-0.62) | 0.50 (0.40-0.59) |
Lymphocytes (median - IQR) | 2.2 (1.9-2.7) | 2.2 (1.7-2.8) | 2.5 (2.0-3.0) | 2.6 (2.10-3.05) |
Clinical and laboratory characteristics of healthy controls (HC), subjects with celiac or thyroid diseases (CD_THY), relatives of T1D patients with 0-1 autoantibodies (preT1D_LR), and subjects with type 1 diabetes (T1D). WBC, Neutrophils, Lymphocytes, Monocytes are expressed as 10x3/ul. BMIp, Body Mass Index for age percentile; Aabs, Autoantibodies; TPO, Thyroid peroxidase; TG, Transglutaminase; WBC, White blood cells; NA, not available.