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. 2022 Nov 10;13:6789. doi: 10.1038/s41467-022-34420-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Heatmap showing correlation of LRS and circulating biomarkers at 0 h in trauma patients (n = 121), measured by Spearman correlation coefficients. Asterisks in a and b indicate statistical significance for correlation coefficient. Unadjusted p-values are approximated by using the two-sided t distributions: *<0.05; **<0.01; ***<0.001. b Schematic of proposed paradigm showing the relationship between circulating lipid levels and outcomes after severe injury. Early loss of circulating lipids correlates with adverse outcomes while failure to resolve critical illness is associated with the selective increase in glycerolipids and PE.