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Basel Declaration and unified sets of ethical principles. The 3S and 4F principles could be an important part of the Preamble to an animal research Basel Declaration. The 3Rs are the classical core, enhanced with guidance on the HBA by the 6Ps and the three validities (3Vs). The documents listed in Table 3 and others could be consolidated into a more complete Basel Declaration, modelled after the Helsinki Declaration on human research.
