Table 3.
Animal research declarations, statements and guiding documents. See links and manuscript text for further details.
| International Declarations on Human and Nonhuman Animal Research | |||
|---|---|---|---|
| Declaration | Information about | Proposing Organization | Link |
| Helsinki Declaration (human research) | Prominent international declaration on human medial research and ethics; 10 sections, 37 points | World Medical Association (WMA) | https://www.wma.net/policies-post/wma-declaration-of-helsinki-ethical-principles-for-medical-research-involving-human-subjects/ |
| Basel Declaration (animal research) | Statement on animal research following Basel conference 2010, can be signed online; contains Introduction, Fundamental Principles and Declaration; 16 points together | Basel Declaration Society, now Animal Research Tomorrow | https://animalresearchtomorrow.org/en/basel-declaration |
| International Standards and Guidelines Relating to Research Animals | International standards and guidelines on animal research and ethics - online document links to two other documents (1–2 next) | International Council for Laboratory Animal Science (ICLAS) |
https://iclas.org/harmonization-committee-international-standards/ |
| 1. Use of Animals in Research and Education | Detailed statement on animal research and education; Chapter 7.8 of Terrestrial Animal Health Code; 10 articles; incorporates 3Rs | World Organization for Animal Health (OiE) | https://www.oie.int/en/what-we-do/standards/codes-and-manuals/terrestrial-code-online-access/?id=169&L=0&htmfile=chapitre_aw_research_education.htm |
| 2. International Guiding Principles for Biomedical Research Involving Animals | International Guiding Principles for Animal Biomedical Research; Preamble and 10 statements | Council of International Organizations of Medical Sciences (CIOMS) & International Council for Laboratory Animal Science (ICLAS) | https://iclas.org/cioms-iclas-international-guiding-principles-for-biomedical-research-involving-animals/ |
| Additional Guidance Documents | |||
| Accreditation for Laboratory Animal Care | International accreditation sensitive to national guidelines; relies on 1. and 2. documents above | American Association for Accreditation of Laboratory Animal Care (AALAC) | https://www.aaalac.org/ |
| European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes | European animal research harmonization document, 38 articles | Council of Europe (ETS 123) | https://www.aaalac.org/pub/?id=E900CF34-9112-946E-C8A5-331F9E2897D9 |
| Guide for the Care and Use of Laboratory Animals (ILAR) | US guide for the care and use of research animals | National Research Council, U.S.A. | https://www.nap.edu/catalog/12910/guide-for-the-care-and-use-of-laboratory-animals-eighth |
| U.S. Government Principles for the Utilization and Care of Vertebrate Animals Used in Testing, Research, and Training | National Institutes of Health (US) vertebrate animal research guidelines | National Institutes of Health, U.S.A. | https://olaw.nih.gov/policies-laws/gov-principles.htm |
| Non-human primate accommodation, care and use guidelines | Guidelines for nonhuman primates, integrates 3Rs and exceeds other nonhuman primate guidelines | National Centre for the Replacement, Refinement & Reduction of Animals in Research (NC3Rs) | https://nc3rs.org.uk/3rs-resources/non-human-primate-accommodation-care-and-use-guidelines |
| ARRIVE Guidelines 2.0 | Animal Research Reporting of In Vivo Experiments (ARRIVE) guidelines, including essential and recommended items | du Sert et al., PLoS Biology 2020 | https://arriveguidelines.org/ |
| PREPARE Guidelines | Planning Research and Experimental Procedures on Animals: Recommendations for Excellence | Smith et al., Lab. Anim. 2018 | https://pubmed.ncbi.nlm.nih.gov/28771074/ |