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. 2022 Nov 10;10(21):e15510. doi: 10.14814/phy2.15510

FIGURE 1.

FIGURE 1

Experimental protocol and basic physiological measurements for PCK rats treated with ivermectin. (a) Experimental protocol showing that 4 groups of PCK male rats were fed a standard Purina 5001 diet and water (control, N = 16) or ivermectin in concentrations 0.5 mg/L (N = 17), 5 mg/L (N = 10), and 50 mg/L (N = 8) for 42 days starting at 6 weeks of age. Total body weight (TBW, b), heart weight (c), heart weight to total body weight ratio (Heart Weight/TBW, d), left kidney weight (LK, e), right kidney weight (RK, f), and 2 kidney weight to total body weight ratio (2 K/TBW, %were measured at the end of the protocol, g). Data were expressed as mean ± SEM and compared using one‐way ANOVA followed by a Tukey post hoc test. *p < 0.05, **p < 0.01, ***p < 0.001.