Figure 5.

HBO1-mediated Kbz is associated with diverse cellular processes

(A) Volcano map shows the dynamics of Kbz sites in response to HBO1 overexpression. Quantitative proteomic analysis was performed with three biological replicates in response to HBO1 overexpression in 293T cells. When log2 (overexpression/control) > 1 and p < 0.05, the quantified Kbz sites were considered significantly upregulated.

(B) Dynamics of histone Kbz sites in response to HBO1 overexpression. Histograms show significantly upregulated core histone sites. Data are represented as mean ±SEM.

(C) Motifs of the residues around the Kbz sites identified in mammalian cells (left) and reported in S. cerevisiae (right), respectively.

(D–F) (D) GO-MF term GSEA, (E) GO-BP term enrichment, and (F) KEGG pathway analysis of the proteins bearing HBO1-targeted Kbz sites.