Table 3.

Unadjusted and adjusted Poisson mixed models testing the effect of sertraline, compared with placebo, on the total number of positive or negative hits (separate models for positive and negative hits as the outcome)

	Positive hits			Negative hits
Model	n	Hits ratio (95% CI)	p value	n	Hits ratio (95% CI)	p value
Unadjusted	576	0.98 (0.89–1.08)	0.66	576	0.99 (0.89–1.10)	0.81
Partially adjusteda	574	0.99 (0.91–1.07)	0.73	574	0.99 (0.91–1.08)	0.85
Fully adjustedb	574	0.98 (0.90–1.06)	0.56	574	0.99 (0.91–1.08)	0.85

Note. 95% CI, 95% confidence interval. Hits ratio can be interpreted the number of hits in the sertraline group relative to the number of hits in the placebo group.

^aAdjusted for randomisation stratification variables (CIS-R total score, duration of depression, site), time, and positive and negative false alarms at all times. For positive hits as the outcome, it was also adjusted for baseline positive hits and negative hits at all times. For negative hits as the outcome, it was also adjusted for baseline negative hits and positive hits at all times.

^bPartially adjusted model further adjusted for variables which were imbalanced at baseline (sex and marital status).