Table 4.

Unadjusted and adjusted Poisson mixed models testing the effect of sertraline, compared with placebo, on the total number of hits

		Model 1: Effect of treatment allocation		Model 2: Interaction between treatment allocation and hits
Models	n	Hits ratio (95% CI)	p value	Hits ratio (95% CI)	p value
Unadjusted	576	0.99 (0.90–1.08)	0.74	1.01 (0.91–1.13)	0.82
Partially adjusteda	574	0.99 (0.93–1.06)	0.75	1.01 (0.90–1.13)	0.87
Fully adjustedb	574	0.98 (0.92–1.05)	0.61	1.01 (0.90–1.13)	0.87

Note. 95% CI, 95% confidence interval. Hits ratio can be interpreted as the number of hits in the sertraline group relative to the number of hits in the placebo group.

For each model type (each row in the table), two models were run. Model 1 tested the effect of treatment allocation on hits, including valence as an exposure. Model 2 tested the interaction between treatment allocation and word valence on hits. All models included participants as a random intercept.

^aAdjusted for randomisation stratification variables (CIS-R total score, duration of depression, site), time, baseline positive and negative hits, and positive and negative false alarms at all times.

^bPartially adjusted model further adjusted for variables which were imbalanced at baseline (sex and marital status).