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. 2022 Nov 8;25(11):105446. doi: 10.1016/j.isci.2022.105446

Figure 6.

Figure 6

TMEM16A deletion leads to enhanced apoptosis and ER stress in myoblasts

(A and B) Western blotting shows the expression of cleaved caspase 3 and caspase 3 protein levels in the KO versus CTR myoblasts during myogenic differentiation. n = 3. Data are mean ± SD. ∗∗∗p < 0.001.

(C) The impaired myogenic differentiation in the KO myoblasts was improved using pan-caspase inhibitor Z-VAD-FMK. Scale bars, 20 μm.

(D) The fusion index analysis in (C). n = 3. Data are mean ± SD. ∗p < 0.05.

(E and F) Western blotting shows the expression of cleaved caspase 12 and pro-caspase 12 protein levels in the KO versus CTR myoblasts during myogenic differentiation. n = 3. Data are mean ± SD. ∗p < 0.05.