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Working scheme of the modulatory roles of TMEM16A in myoblast
Intracellular TMEM16A in myoblast modulates the Ca2+ release from ER through IP3R calcium channels to coordinate the processes of proliferation and myogenic differentiation. Cl− effects as counter ion by binding Ca2+ and modulates the calcium homeostasis in ER and global calcium transients. TMEM16A deletion causes the disturbance of ER calcium homeostasis and global calcium.
