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. 2020 Dec 14;52(13):2722–2730. doi: 10.1017/S0033291720004821

Table 3.

Total, direct and indirect effects for frequent or distressing PEs

	PEs (12–18)^a						PEs (19–24)^b
	Unadjusted			Adjusted^c			Unadjusted			Adjusted^c
	OR	95% CI	p	OR	95% CI	p	OR	95% CI	p	OR	95% CI	p
Total causal effect	1.48	1.26–1.73	<0.001	1.48	1.25–1.75	<0.001	1.56	1.24–1.88	<0.001	1.57	1.28–1.92	<0.001
Natural direct effect	1.38	1.17–1.63		1.40	1.18–1.67		1.51	1.20–1.80		1.51	1.24–1.84
Natural indirect effect	1.07	1.02–1.12		1.05	1.01–1.10		1.03	0.98–1.09		1.03	0.98–1.09
Proportion mediated	17%			14%			8%			8%

^a

Study of adolescent PEs, N = 2952.

^b

Study of adult PEs, N = 2492.

^c

Confounders adjusted for: sex and family history of mental health illness.