Table 3.
Univariate odds ratios (95% confidence intervals) for selected risk factors, clinical presentation, angiographic findings and outcomes in women and men with premature and very premature CAD as compared to non-premature CAD. Univariate ORs <1.00 indicate that these variables are more important in non-premature CAD while >1.00 indicate that these are more important in premature CAD.
| Variable | Women |
Men |
||
|---|---|---|---|---|
| Premature | Very premature | Premature | Very premature | |
| Hypertension | 0.67(0.50–0.90)∗ | 0.27(0.16–0.47)∗∗∗ | 0.49(0.42–0.57)∗∗∗ | 0.22(0.15–0.32)∗∗∗ |
| Diabetes | 1.07(0.81–1.42) | 0.51(0.28–0.93)∗ | 0.78(0.67–0.92)∗∗ | 0.33(0.22–0.51)∗∗∗ |
| Cholesterol ≥200 mg/dl | 1.52(1.03–2.25)∗ | 1.59(0.79–3.20) | 1.73(1.38–2.17)∗∗∗ | 1.92(1.22–3.03)∗∗ |
| Cholesterol ≥170 mg/dl | 1.53(1.13–2.07)∗∗∗ | 1.25(0.70–2.24) | 1.67(1.42–1.98)∗∗∗ | 1.61(1.13–2.30)∗∗∗ |
| Non-HDL cholesterol ≥130 mg/dl | 1.84(1.35–2.52)∗∗∗ | 1.32(0.72–2.42) | 1.69(1.43–1.90)∗∗∗ | 1.67(1.17–2.34∗∗) |
| Non-HDL cholesterol ≥100 mg/dl | 1.59(1.21–2.11)∗∗∗ | 2.26(1.31–3.90)∗∗ | 1.48(1.27–1.72)∗∗∗ | 1.92(1.38–2.67)∗∗∗ |
| LDL cholesterol ≥100 mg/dl | 0.94(0.73–1.22) | 1.13(0.71–1.79) | 1.10(0.95–1.25) | 1.04(0.77–1.41) |
| LDL cholesterol ≥70 mg/dl | 1.07(0.86–1.33) | 0.96(0.63–1.46) | 1.01(0.89–1.13) | 0.96(0.73–1.24) |
| Triglycerides ≥150 mg/dl | 1.01(0.77–1.31) | 0.98(0.59–1.64) | 1.03(0.89–1.19) | 0.94(0.68–1.31) |
| Smoking/tobacco | 1.40(0.84–2.35) | 2.14(0.95–4.82) | 1.63(1.34–1.98) | 1.27(0.81–1.97) |
| CKD, creatinine ≥2 mg/dl | 0.38(0.08–1.75) | – | 0.52(0.30–0.95)∗ | 1.01(0.36–2.82) |
| Uninsured status | 0.81(0.61–1.08) | 0.43(0.25–0.74)∗∗ | 0.83(0.72–0.97)∗ | 0.59(0.42–0.82)∗∗ |
| STEMI | 1.13(0.85–1.51) | 1.29(0.75–2.22) | 1.35(1.16–1.56) | 1.79(1.29–2.49) |
| NSTEMI/Unstable angina | 0.87(0.66–1.15) | 0.91(0.53–1.56) | 0.76(0.65–0.88) | 0.57(0.41–0.79) |
| EF <45% | 0.67(0.49–0.90)∗ | 1.0(0.58–1.72) | 1.08(0.93–1.26) | 1.07(0.77–1.50) |
| Single vessel disease | 1.11(0.84–1.48) | 0.99(0.58–1.70) | 1.09(0.94–1.26) | 0.95(0.69–1.33) |
| Triple vessel disease | 0.77(0.54–1.09) | 0.75(0.38–1.48) | 0.90(0.74–1.08) | 1.03(0.68–1.54) |
| Stents ≥2 deployed | 0.85(0.64–1.13) | 0.68(0.38–1.20) | 0.83(0.71–0.97)∗ | 0.64(0.42–0.89)∗ |
| In-hospital deaths | 0.59(0.11–2.65) | – | 1.22(0.63–2.36) | 1.17(0.28–4.94) () |
CKD chronic kidney disease; HDL high density lipoprotein; LDL low-density lipoprotein; NSTEMI non-ST segment elevation myocardial infarction; STEMI ST segment elevation myocardial infarction; ∗p < 0.05, p∗∗<0.01, ∗∗∗p < 0.001.