TABLE 3.
Pathways enriched by gene set enriched pathways of differentially expressed proteins in PSP compared to PD. Differentially expressed proteins selected by both volcano plot and bootstrap ROC analysis were used for this analysis
| Term | Count | a PH | % | p Value |
|---|---|---|---|---|
| Parkinson's disease | 60 | 142 | 42.3 | 3.80E‐38 |
| Oxidative phosphorylation | 55 | 133 | 41.4 | 2.70E‐34 |
| Alzheimer's disease | 58 | 168 | 34.5 | 3.10E‐31 |
| Huntington's disease | 59 | 192 | 30.7 | 1.00E‐28 |
| Non‐alcoholic fatty liver disease (NAFLD) | 49 | 151 | 32.5 | 6.30E‐25 |
| Cardiac muscle contraction | 24 | 75 | 32.0 | 4.40E‐12 |
| Spliceosome | 26 | 133 | 19.5 | 4.10E‐08 |
| Metabolic pathways | 109 | 1219 | 8.9 | 5.00E‐08 |
| Pancreatic secretion | 15 | 93 | 16.1 | 4.90E‐04 |
| Salivary secretion | 13 | 86 | 15.1 | 2.40E‐03 |
a
PH, the total number of proteins in the pathway.