Fig. 8.

Sub-cluster analysis of neurons reveals immature and mature neuron sub-populations associated with RML disease. A UMAP projection of all 8,244 neurons clustered into immature and mature neuron sub-types. B The relative proportion of each neuron sub-cluster is plotted for the cortex and hippocampus of RML and mock infected mice. p values were calculated using non-parametric Mann–Whitney U tests. * p values  < 0.1, ** p values  < 0.05, *** p values  < 0.01. All p values are provided in additional file 7. npc—neural progenitor cell; diff.neu—differentiating neuron; cr.neu—cajal retzius neuron; m.neu—mature neuron; ex.neu—excitatory neuron; inh.neu—inhibitory neuron