Figure 3.
lncRNA genes are enriched for roles in promoting neural induction
(A) Distributions of genome-wide ρ values for coding and lncRNA hits in PAX6 marker-based differentiation screens. ∗p < 1 × 10−6 by permutation test.
(B) Distributions of genome-wide γ values for coding and lncRNA hits in growth-based proliferation screens. ∗p < 1 × 10−6 by permutation test.
(C) Scatterplots showing both differentiation (ρ) and proliferation (γ) phenotypes for all screened genes, with hits colored by their primary phenotype (differentiation, blue; proliferation, orange; or dual, purple) and non-hits shown in gray.
(D) Venn diagrams showing relative breakdown of coding and lncRNA hits by their primary phenotypes, drawn to scale.
(E) Ratio of differentiation to proliferation hits for coding genes and lncRNAs in neural induction. ∗p < 1 × 10−6 by permutation test.