Figure 5.
A small fraction of lncRNA gene hits have evidence of enhancer-like function
(A) Diagram of screen hits that map to enhancer sequences across FANTOM5 atlas and MPRA neural induction enhancer datasets.
(B) Bar plots showing fraction of coding and lncRNA genes (colored, hit; gray, non-hit) mapping to enhancers described in (A).∗p < 0.05 comparing hits and non-hits by Fisher exact test; n.s., non-significant.
(C) Diagram of close-range lncRNA-coding hit pair genomic relationships.
(D) Bar plots showing fraction of coding and lncRNA genes (colored, hit; gray, non-hit) in each category described in (C). ∗p < 0.05 comparing hits and non-hits by Fisher exact test; n.s., non-significant.
(E) Diagram of long-range 3D chromatin interactions between lncRNA and coding hit pairs.
(F) Histogram showing distances of long-range 3D gene-gene looping interactions identified by PLAC-seq. Interaction hits are colored in light red; all other interactions in gray.
(G) Venn diagrams showing potential enhancer-like screen hits classified into the categories detailed above.