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. 2022 Sep 8;2(9):951–965. doi: 10.1158/2767-9764.CRC-22-0256

FIGURE 5.

FIGURE 5

Effect of a KG on glycolytic pathway in pancreatic tumors. A, GSEA was conducted on RNA-seq data obtained from pancreatic tumors of KG- and CG-treated KPC mice. The enrichment plot for the Glycolysis gene set upregulated by KG treatment (relative to CG) is depicted. Normalized enrichment score (NES) and nominal P value (P) were provided according to GSEA. B, Immunoblots of HK2 in pancreatic tumor homogenates isolated from CD-, KD-, CG-, and KG-treated KPC mice at endpoint. Loading control: β-actin. Bands were quantified and results are expressed as % control; *, P < 0.05. C, Immunoblots of HK2 in pancreatic tumor homogenates isolated from CG- and KG-treated KPC mice following 2 months of treatment. Loading control: β-actin. Bands were quantified and results are expressed as % control.