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. 2022 Sep 8;2(9):951–965. doi: 10.1158/2767-9764.CRC-22-0256

FIGURE 6.

FIGURE 6

Effect of a KG on lipid metabolism in pancreatic tumors. A, GSEA was conducted on RNA-seq data obtained from pancreatic tumors of KG- and CG-treated KPC mice. The enrichment plot for the Lipid_Metabolism gene set upregulated by KG treatment (relative to CG) is depicted. Normalized enrichment score (NES) and nominal P value (P) were provided according to GSEA. B, Levels of SFAs, MUFA, PUFAs, as well as the n-6/n-3 fatty acid ratio in pancreatic tumors isolated from CG- and KG-treated KPC mice following 2 months of treatment. C, Concentrations (% of total fatty acids) of selected fatty acids (asclepic acid, palmitoleic acid, margaric acid, and eicosatrienoic acid) in pancreatic tumors homogenates isolated from CG- and KG-treated KPC mice (male and females combined) following 2 months of treatment. D, Concentrations (% of total fatty acids) of selected fatty acids (palmitic acid, margaric acid, myristoleic acid, palmitoleic acid, linoleic acid, and stearic acid) in pancreatic tumors homogenates isolated from CG- and KG-treated KPC female mice following 2 months of treatment. *, P < 0.05; **, P < 0.01.