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. 2022 Nov 10;32(12):1068–1085. doi: 10.1038/s41422-022-00746-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Schematic diagram of rabbit immunization with HR121 formulated with CFA and IFA (n = 4) or CFA/IFA only (n = 2). b Endpoint titers of bAbs to purified SARS-CoV-2 HR proteins in HR121-immunized rabbits. P values were determined by ordinary one-way ANOVA. c, d nAbs to SARS-CoV-2 pseudovirus and authentic virus in HR121-immunized rabbits. nAbs in rabbit sera are presented with NT₅₀s (c), and nAbs in IgGs purified from sera with IC₅₀s (d). e Schematic diagram of rabbit immunization with HR12 with CFA/IFA (n = 3) or CFA/IFA only (n = 2). f Comparison of bAbs to HR12 protein between HR12 immunization and HR121 immunization. g Comparison of nAbs to SARS-CoV-2 pseudovirus between HR12 immunization and HR121 immunization. h bAbs to HR proteins in sera from human COVID-19 convalescent (n = 11) and vaccinated individuals (n = 9). i, j Inhibitions of HR121 and HR2 binding by sera (i) and IgGs (j) from HR121-immunized rabbits were determined by a competitive ELISA, and inhibitions by sera from human COVID-19 convalescents (n = 11) and vaccinated individuals (n = 9) were also evaluated. ND, not determined. k Dose-dependent curves of rabbit anti-HR121 sera to 23 current SARS-CoV-2 pseudo-variants. The NT₅₀s are marked (dashed lines) and calculated by GraphPad Prism 8.0.1. In b–d, f, g, and h–j, data are presented as geometric mean ± geometric standard deviation (SD), and horizontal dashed lines mean the limit of quantification.