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. 2022 Nov 10;32(12):1068–1085. doi: 10.1038/s41422-022-00746-3

Fig. 4. HR121 induced highly potent nAbs in hACE2 transgenic mice against SARS-CoV-2 infection.

Fig. 4

a Schematic illustration of hACE2 mouse vaccination with HR121 and challenge with SARS-CoV-2. b bAbs to HR121. c nAbs to authentic SARS-CoV-2. Two mice vaccinated with HR121 were not examined for their low volumes of sera. d Pulmonary viral gRNA loads. e Pulmonary sgRNA loads. f Heatmap of pulmonary cytokine expressions. RNA levels of antiviral and pro-inflammatory cytokine genes in the groups of adjuvant and HR121 (6/8 in each group) were normalized to those of uninfected controls (n = 3). Data are presented as median ± interquartile range. Differences between adjuvant and HR121 groups were determined by two-tailed Mann-Whitney test. *P < 0.05, **P < 0.01. g Representative photographs of H&E staining, in which infiltration of lymphocytes and macrophages (blue arrow), detached bronchial mucosa (red arrow) and thickened alveolar walls (green arrow) in PBS and adjuvant controls are marked. In b–e, each circle/dot represents a mouse, and dashed lines represent the limit of quantification. Data are presented as geometric mean ± geometric SD. In d and e, data are presented as median ± interquartile range (two-tailed Mann-Whitney test).