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. 2022 Nov 10;32(12):1068–1085. doi: 10.1038/s41422-022-00746-3

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© The Author(s) 2022

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Fig. 5 — a Schematic illustration of vaccination of two groups of hamsters with HR121. They were divided into a STP group and a LTP group. b bAbs to HR121. c nAbs against authentic SARS-CoV-2. Four and two hamsters in the STP an LTP groups were not examined for the low volumes of sera obtained, respectively. d Dose-dependent curve of nAbs to authentic SARS-CoV-2. e, f Pulmonary viral gRNA (e) and sgRNA (f) in STP group. g, h Pulmonary viral gRNA (g) and sgRNA (h) in LTP group. i, j Representative photographs of pulmonary H&E staining in the STP group (i) and LTP group (j), in which infiltration of lymphocytes and macrophages (blue arrow), detached bronchial mucosa (red arrow), and diffuse alveolar damage (green arrow) in PBS or adjuvant controls are marked. In b, c and e–h, each circle/dot represents a hamster, and dashed lines mean limit of quantification. In d, each line represents a hamster. In b and c, data are presented as geometric mean ± geometric SD (two-tailed Mann-Whitney test). In e–h, data are presented as median ± interquartile range (two-tailed Mann-Whitney test).