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. 2022 Nov 10;32(12):1068–1085. doi: 10.1038/s41422-022-00746-3

Fig. 7. Vaccination with HR121 formulated with aluminum or Freund’s adjuvant (CFA/IFA) resulted in similarly effective protection of Syrian golden hamsters against challenge with SARS-CoV-2 Omicron BA.2 variant.

Fig. 7

a Schematic illustration of injection of four groups of hamsters (n = 12 per group) with HR121 plus CFA/IFA (Group 1), CFA/IFA only (Group 2), HR121 plus aluminum adjuvant (Group 3), and aluminum adjuvant only (Group 4). b bAbs to HR121. c nAbs against authentic SARS-CoV-2 Omicron BA.2 variant. d, e Pulmonary viral gRNA (d) and sgRNA (e) in the four groups. f Representative photographs of pulmonary H&E staining in the four groups, in which infiltration of lymphocytes and macrophages (blue arrow), and alveolar damage (green arrow) in the adjuvant only controls are marked. In b–e, each circle/dot represents a hamster; in b and c, the sera of two hamsters in each HR121 vaccination were pooled because of their low volumes. In b–e, dashed lines mean limit of quantification. In b and c, data are presented as geometric mean ± geometric SD (two-tailed Wilcoxon test). In d and e, data are presented as median ± interquartile range (two-tailed Wilcoxon test).