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. Author manuscript; available in PMC: 2022 Nov 14.
Published in final edited form as: Cell Rep. 2022 Sep 27;40(13):111417. doi: 10.1016/j.celrep.2022.111417

Figure 1. FMD cycles improve cognitive behavior in female E4FAD mice.

Figure 1.

(A) Experimental diet and behavior schedule for female E4FAD mice starting at 2.5 months of age through 7–7.5 months of age.

(B) SAB percentage for E4FAD females at baseline (2.5 months) and at 6 or 6.5 months after ~3 months of diet (baseline, n = 19; control, 6 months, n = 9; FMD, 6 months, n = 11).

(C) Latency (seconds lapsed before finding escape box) between E4FAD FMD females (n = 20) and E4FAD females on control diet (n = 19) in the Barnes maze at approximately 6.5–7 months.

(D) Success rate in finding the escape box between E4FAD FMD females (n = 20) and E4FAD females on control diet (n = 19) in the Barnes maze at approximately 6.5–7 months.

(E) Strategies (random, serial, and spatial) used by female E4FAD control group (n = 19) to locate escape box.

(F) Strategies (random, serial, and spatial) used by female E4FAD FMD group (n = 20) to locate escape box. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, and ****p < 0.0001, unpaired two-tailed student’s t test (SAB). Two-way ANOVA (Barnes maze).