FIG. 1.

Proliferative responses of LN cells from HLA-DRB1*01-transgenic mice (black bars) and control FVB mice (white bars). Mice (two males per group) were primed by footpad inoculation with 50 μg of peptide 206–224 of M. leprae (Ml) or M. avium (Ma) or 25 μg of rpL35 (rP) in incomplete Freund’s adjuvant. [³H]thymidine uptake corrected for phosphate-buffered saline controls of pooled 8-day primed LN cells incubated in the presence of 50 μg of peptide or protein stimuli per ml was measured for transgenic and control mice. Anti-HLA-DR monoclonal Ab inhibited 53.3% of the M. leprae 206–224-specific response and not the rpL35 stimulation of DR1 transgenic LN cells (results not shown). *31000, counts per minute.