Figure 2.

The effects of rhein on gut microbial composition and structure in mice (n =5). (A) Alpha diversity. (B) Beta diversity was determined by the Bray–Curtis distance-based principal. (C) predominant fecal microbial communities, and different bacteria at the phylum, family, and genus levels. (The symbol * indicates statistically significant differences between two groups, *p < 0.05 and **p < 0.01, one-way ANOVA). (D) The linear discriminant analysis effect size (LEfSe) analysis identified gut bacterial biomarkers in mice in three group.