Table 2.
Significantly up-regulated genes (-5<Log2FC<5, Padjust<0.05) upon exposure of D-DalN/LPS compared to the control group.
| Gene name | Log2FC (Model/NC) | Padjust (NC/Model) | Padjust (Model/Rhein) |
|---|---|---|---|
| Car4 | 6.919175284 | 0.00 | 0.00 |
| Timp1 | 6.944975523 | 0.00 | 0.04 |
| Tgfb1 | 5.151649063 | 0.00 | 0.00 |
| Ier3 | 5.506764099 | 0.00 | 0.00 |
| Hmox1 | 5.212161173 | 0.00 | 0.00 |
| Adamts4 | 6.706936815 | 0.00 | 0.03 |
| Ccl8 | 5.324963207 | 0.00 | 0.00 |
| Stc1 | 6.06811393 | 0.00 | 0.03 |
| Slamf1 | 5.655920857 | 0.00 | 0.00 |
| Il10 | 6.751278575 | 0.00 | 0.00 |
| Cd40 | 6.349012026 | 0.00 | 0.03 |
| Adora2b | 5.320542683 | 0.00 | 0.01 |
| Plek | 6.476748845 | 0.00 | 0.00 |
| Adora2a | 5.050565758 | 0.00 | 0.02 |
| Gfpt2 | 5.366385622 | 0.00 | 0.01 |
| Pik3r5 | 5.153700574 | 0.00 | 0.00 |
| Arg2 | 6.261374572 | 0.00 | 0.00 |
| Acod1 | 10.4080818 | 0.00 | 0.05 |
| Samsn1 | 6.538537579 | 0.00 | 0.00 |
| Cdkn1a | 6.453109266 | 0.00 | 0.04 |
| Gzma | 5.062957775 | 0.00 | 0.00 |
| Apom | 5.116050176 | 0.00 | 0.01 |
| Tnf | 7.491073348 | 0.00 | 0.00 |
| Hbegf | 6.132634273 | 0.00 | 0.00 |
| Ms4a4c | 5.40723121 | 0.00 | 0.01 |
| Ms4a6d | 5.985060818 | 0.00 | 0.00 |
| Slc16a3 | 6.097855153 | 0.00 | 0.00 |
| Il6 | 6.740192438 | 0.00 | 0.01 |
| Ccr1 | 5.242404986 | 0.00 | 0.00 |
| Sema4c | 6.110668584 | 0.00 | 0.02 |
| Gpr35 | 6.249355827 | 0.00 | 0.00 |
| Ifi211 | 6.64611414 | 0.00 | 0.01 |
| Sell | 5.184631989 | 0.00 | 0.00 |
| Il1b | 5.774572407 | 0.00 | 0.00 |
| Procr | 6.322937193 | 0.00 | 0.00 |
| Glipr2 | 7.662069079 | 0.00 | 0.03 |
| Tnfrsf9 | 7.222147271 | 0.00 | 0.00 |
| Bst1 | 7.000658331 | 0.00 | 0.00 |
| Ppbp | 6.533548869 | 0.00 | 0.00 |
| Ereg | 7.283104436 | 0.00 | 0.01 |
| Clec4e | 7.841833483 | 0.00 | 0.00 |
| Clec4d | 7.743163983 | 0.00 | 0.00 |
| Olr1 | 6.171770662 | 0.00 | 0.04 |
| Pglyrp1 | 6.041945188 | 0.00 | 0.00 |
| Siglece | 5.451987043 | 0.00 | 0.00 |
| Adm | 5.451046818 | 0.00 | 0.00 |
| Il2rg | 5.922866163 | 0.00 | 0.01 |
| Angpt2 | 5.046610524 | 0.00 | 0.00 |
| Ngp | 6.211127623 | 0.00 | 0.00 |
| Ptgs2 | 7.49760651 | 0.00 | 0.00 |
| AA467197 | 7.869514992 | 0.00 | 0.00 |
| Batf | 6.738098848 | 0.00 | 0.00 |
| Jdp2 | 5.270912884 | 0.00 | 0.03 |
| Dbn1 | 6.522036342 | 0.00 | 0.00 |
| Ccl5 | 5.736058999 | 0.00 | 0.01 |
| Serpine1 | 6.105035149 | 0.00 | 0.00 |
| Egr2 | 6.365133619 | 0.00 | 0.00 |
| Slamf7 | 5.910760118 | 0.00 | 0.00 |
| Batf2 | 5.665438455 | 0.00 | 0.02 |
| Spsb1 | 5.327076278 | 0.00 | 0.02 |
| Chil3 | 8.006701052 | 0.00 | 0.00 |
| Serpina3g | 5.669202334 | 0.00 | 0.03 |
| Trem3 | 5.377878513 | 0.00 | 0.03 |
| Trem1 | 6.934995142 | 0.00 | 0.00 |
| Ccno | 5.265875138 | 0.00 | 0.00 |
| Il1f9 | 8.283161225 | 0.00 | 0.01 |
| Fpr1 | 5.057008415 | 0.00 | 0.00 |
| Plaur | 5.781148943 | 0.00 | 0.01 |
| Marcksl1 | 5.065599451 | 0.00 | 0.02 |
| Selplg | 5.380248123 | 0.00 | 0.00 |
| Tmem252 | 5.608693398 | 0.00 | 0.03 |
| Rasd1 | 5.127485541 | 0.00 | 0.00 |
| Lrrc25 | 5.036998147 | 0.00 | 0.01 |
| Fpr2 | 5.34870867 | 0.00 | 0.00 |
| Hbb-bs | 6.318989389 | 0.00 | 0.00 |
| S100a8 | 7.009760337 | 0.00 | 0.02 |
| S100a9 | 7.779229798 | 0.00 | 0.00 |
| Capg | 5.48152647 | 0.00 | 0.00 |
| Cxcl2 | 9.817770623 | 0.00 | 0.00 |
| Osm | 5.163056101 | 0.00 | 0.04 |
| Nfe2 | 5.860432292 | 0.00 | 0.02 |
| Fcgr4 | 5.007453977 | 0.00 | 0.00 |
| Chil1 | 7.752737989 | 0.00 | 0.01 |
| Snora73a | 5.780667664 | 0.00 | 0.00 |
| Hba-a2 | 5.89064318 | 0.00 | 0.00 |
| Hba-a1 | 5.840920595 | 0.00 | 0.00 |
| Rps13-ps2 | 7.199941268 | 0.00 | 0.00 |
| Sp110 | 5.580940347 | 0.00 | 0.04 |
| Hbb-bt | 5.972566189 | 0.00 | 0.00 |
| 7.367754009 | 0.00 | 0.00 | |
| Ms4a6c | 5.06313634 | 0.00 | 0.00 |
| Cstdc4 | 7.270625276 | 0.00 | 0.02 |
| Dnah2os | 5.722701063 | 0.00 | 0.00 |
| Snora81 | 7.677871672 | 0.00 | 0.03 |
| Apold1 | 5.765146149 | 0.00 | 0.00 |
| Ms4a4a | 6.453485429 | 0.00 | 0.00 |
| Bcl2a1a | 7.012518761 | 0.00 | 0.04 |
| Usf2-ps1 | 7.124584422 | 0.00 | 0.00 |
| 7SK | 7.365687369 | 0.00 | 0.01 |
The genes significantly recovered after rhein treatment (Padjust<0.05).