Table 1.
Baseline clinical characteristics.
| MPO-AAV (n = 109) | DPPs (n = 20) | Anti-GBM (n = 23) | p value | ||
|---|---|---|---|---|---|
| Age (year) (mean, SD) | 54.17 ± 16.37 | 64.50 ± 9.77 a | 41.78 ± 14.55a,b | <0.0001 | |
| Sex (male/female) | 58/51 | 12/8 | 3/10 | 0.842 | |
| Neutrophil (109/L) (mean, SD) | 7.03 ± 4.62 | 6.66 ± 2.10 | 7.29 ± 3.85 | 0.887 | |
| Lymphocyte (109/L) (mean, SD) | 1.45 ± 1.55 | 0.99 ± 0.40 | 1.31 ± 0.68 | 0.365 | |
| Hemoglobin (g/L) (mean, SD) | 81.61 ± 17.20 | 77.85 ± 10.38 | 81.04 ± 19.55 | 0.659 | |
| Platelet (109/L) (mean, SD) | 256.38 ± 106.57 | 262.60 ± 115.88 | 252.52 ± 106.51 | 0.953 | |
| Serum albumin (g/L) (mean, SD) | 39.71 ± 14.24 | 37.31 ± 14.67 | 27.57 ± 5.05a,b | 0.001 | |
| Serum globulin (g/L) (mean, SD) | 31.97 ± 6.63 | 32.88 ± 7.42 | 27.76 ± 6.88a,b | 0.017 | |
| Urinary protein (g/24 h) (median, IQR) | 1.53 (0.85,3.70) | 1.03 (0.50,3.42) | 3.06 (1.26,5.00) | 0.17 | |
| Serum creatinine (μmol/L) (mean, SD) | 374.88 ± 251.15 | 514.53 ± 241.32 a | 826.29 ± 403.70a,b | <0.0001 | |
| eGFR (ml/min per 1.73 m2) (median, IQR) | 18.02 (8.50,27.77) | 8.58 (6.60,16.90) a | 5.39 (3.82,13.13) a | <0.0001 | |
| CRP (mg/dL) (median, IQR) | 16.20 (4.99,41.80) | 24.20 (9.88,89.30) | 31.75 (5.86,110.00) | 0.113 | |
| ESR (mm/h) (median, IQR) | 71 (42,110) | 86 (35,120) | 41 (20,100) | 0.093 | |
| Serum immunological indexes | |||||
| sC3 (mg/L) (mean, SD) | 819.92 ± 243.45 | 807.20 ± 190.96 | 896.09 ± 273.21 | 0.357 | |
| sC4 (mg/L) (mean, SD) | 264.65 ± 110.07 | 225.87 ± 57.04 | 277.65 ± 96.20 | 0.218 | |
| sIgA (mg/L) (mean, SD) | 2674.11 ± 1407.03 | 2229.05 ± 1017.77 | 2229.87 ± 1378.32 | 0.198 | |
| sIgG (g/L) (mean, SD) | 14.67 ± 4.79 | 14.80 ± 5.75 | 9.49 ± 4.63a,b | <0.0001 | |
| sIgM (mg/L)(mean, SD) | 1121.20 ± 659.87 | 1056.35 ± 350.08 | 975.00 ± 531.31 | 0.562 | |
| Organ involvement | |||||
| Kidney, n% | 109 (100.00) | 20 (100.00) | 23 (100.00) | 1.0000 | |
| Pulmonary, n% | 60 (55.05) | 15 (75.00) | 10 (43.48) | 0.111 | |
| Cardiovascular, n% | 14 (12.84) | 6 (30.00) | 0 (0.00) b | 0.014 | |
| Nervous system, n% | 13 (11.93) | 3 (15.00) | 0 (0.00) | 0.139 | |
| BVAS (mean, SD) | 16.31 ± 5.75 | 16.55 ± 5.78 | – | 0.865 | |
| ESRD, n (%) | 37 (33.94) | 15 (75.00) a | 19 (82.61) a | <0.0001 | |
| Mortality, n (%) | 9 (8.26) | 6 (30.00) a | 2 (8.70) | 0.001 | |
eGFR, estimated glomerular filtration rate; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; BVAS, birmingham vasculitis activity score; ESRD, end stage renal disease;
a
p < 0.05 vs. MPO-AAV and bp < 0.05 vs. DPPs.