Table 2.
Pathological features.
| MPO-AAV (n=109) | DPPs (n=10) | Anti-GBM (n=23) | p value | |
|---|---|---|---|---|
| Histological characteristics | ||||
| The proportion of Glomerular sclerosis (median, IQR) | 0.28 (0.13,0.50) | 0.14 (0.03,0.42) | 0.13 (0.00,0.25) | 0.01 |
| The proportion of crescentic glomeruli (median, IQR) | 0.38 (0.16,0.56) | 0.57 (0.51,0.77) a | 0.77 (0.47,0.89) a | <0.0001 |
| The proportion of cellular crescents (median, IQR) | 0.00 (0.00,0.37) | 0.66 (0.17,1.00) a | 0.50 (0.00,1.00) a | <0.0001 |
| The proportion of fibrous crescents (median, IQR) | 0.07 (0.00,0.40) | 0.00 (0.00,0.14) | 0.00 (0.00,0.25) | 0.174 |
| Fibrinoid necrosis, n% | 44 (40.4) | 7 (70.0) | 13 (56.5) | 0.098 |
| Bowman’s capsule rupture, n% | 36 (33.0) | 9 (90.0) a | 15 (65.2) a | <0.0001 |
| Granulomatous lesions, n% | 9 (8.3) | 1 (10.0) | 2 (8.7) | 1.000 |
| TMA, n% | 9 (8.3) | 1 (10.0) | 1 (4.3) | 0.865 |
| Interstitial infiltrates (n, 0/1/2/3) | (0/49/50/10) | (0/3/3/4) | (0/10/12/1) | 0.094 |
| Tubulointerstitial lesions (n, 0/1/2/3) | (0/47/45/17) | (0/3/4/3) | (0/11/11/1) | 0.382 |
| Immunofluorescence pattern (n%) | ||||
| C3 Number of negative | 75 (69.4) | 6 (60.0) | 6 (26.1) | |
| Number of 1+ | 17 (15.7) | 2 (20.0) | 4 (17.4)a,b | <0.0001 |
| Number ≥ 2+ | 16 (14.8) | 2 (20.0) | 13 (56.5) | |
| C4 Number of negative | 83 (86.5) | 9 (90.0) | 3 (30.0) | |
| Number of 1+ | 11 (11.5) | 0 (0.0) | 3 (30.0)a,b | <0.0001 |
| Number ≥ 2+ | 2 (2.1) | 1 (10.0) | 4 (40.0) | |
| C1q Number of negative | 95 (88.8) | 10 (100.0) | 20 (90.9) | |
| Number of 1+ | 9 (8.4) | 0 (0.0) | 2 (9.1) | 1.000 |
| Number ≥ 2+ | 3 (2.8) | 0 (0.0) | 0 (0.0) | |
| IgA Number of negative | 85 (81.0) | 9 (90.0) | 13 (56.5) | |
| Number of 1+ | 17 (15.9) | 0 (0.0) | 6 (26.1) a | 0.032 |
| Number ≥ 2+ | 3 (2.9) | 1 (10.0) | 4 (17.4) | |
| IgG Number of negative | 80 (74.1) | 5 (50.0) | 5 (21.7) | |
| Number of 1+ | 16 (14.8) | 2 (20.0) | 4 (17.4) a | <0.0001 |
| Number ≥ 2+ | 12 (11.1) | 3 (30.0) | 14 (60.9) | |
| IgM Number of negative | 58 (53.7) | 4 (40.0) | 11 (47.8) | |
| Number of 1+ | 23 (21.3) | 2 (20.0) | 5 (21.7) | 0.555 |
| Number ≥ 2+ | 27 (25) | 4 (40.0) | 7 (30.4) | |
TMA, thrombotic microangiopathy; ap < 0.05 vs. MPO-AAV; bp < 0.05 vs. DPPs.