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. Author manuscript; available in PMC: 2022 Nov 14.
Published in final edited form as: ACS Catal. 2021 Jul 2;11(14):8807–8817. doi: 10.1021/acscatal.1c01001

Table 2.

Generality of amine precursors in aminoheteroarylation reactions

graphic file with name nihms-1821252-t0008.jpg

Reaction conditions: 1 (0.2 mmol, 1.0 equiv), 4 (2.0 equiv), Cu(OTf)2 (10 mol %), TsOH∙H2O (1.5 equiv), DCE (1 mL), 80 °C. Isolated yields shown.

a

Run with 4f (3.0 equiv).

b

Run at 40 °C.

c

Run with 4j (4.0 equiv) and TsOH∙H2O (3.0 equiv) at 60 °C.

d

Run at 40 °C.

e

Run with 4n (3.0 equiv) and TsOH∙H2O (2.25 equiv) at 60 °C.

f

Run with 1b (0.1 mmol, 1.0 equiv), 4o (3.0 equiv) and TsOH∙H2O (6.0 equiv).