Table 1. Rat health scoring criteria.

Score	0	1	2	3	4
Weight Loss*	up to 5%	6–10%	11–15%	16–20%	>20%
Temperature*	+0.5°C	+0.6–1.0°C	+1.1–1.5°C	>+2.1°C	<34.0°C
Behavior	normal	less peer interaction	huddled	moved only when prodded	recumbent in cage or unable to stand upright or walk
Appearance	normal	ruffled fur	hunched posture	half-closed eyes or porphyrin staining around eyes/nose/mouth	respiratory distress
Neurological	normal	loss of muscle coordination or head tilt	erratic/easily spooked/jumpy movements, large circles in cage or tremors of the head	small circles in the cage	seizures including rolling in the cage

* based on changes from baseline