TABLE 3.

Final Parameter Estimates Using SSE Method (n = 1000)

Parameter	Description	Median	Mean (±95% CI)	%RSE
Structural model
$CL/F= {\theta }_1\cdot {\left(\frac{Age}{49}\right)}^{{\theta }_2}\cdot \left(PO{D}^{{\theta }_3}inearlyphase\right)\cdot \left(PO{D}^{{\theta }_4}inlatephase\right)$
${\theta }_{1,preop}$	Oral clearance (CL/F) before surgery (L/h) in kidney transplant patient	21.2	21.1 ± 0.0322	1.55
${\theta }_{1,postop,kidney}$	Baseline CL/F after surgery in kidney transplant patients (L/h)	18.8	18.8 ± 0.0224	1.22
${\theta }_{1. postop,liver}$	Baseline CL/F after surgery in liver transplant patients (L/h)	11.4	11.1 ± 0.0159	1.31
${\theta }_2$	Age effect	−0.382	−0.379 ± 0.00418	11.2
${\theta }_{3,kidney}$	POD effect in early period in kidney transplant patient	0.118	0.118 ± 0.000191	1.65
${\theta }_{3,liver}$	POD effect in liver transplant patient	0.0582	0.0585 ± 0.000184	3.03
${\theta }_{4,kidney}$	POD effect in late period in kidney transplant patient	−0.0100	−0.0101 ± 0.000139	14.0
$V/F={\theta }_5\cdot {\left(\frac{WT}{62.4}\right)}^{{\theta }_6}$
${\theta }_5$	Apparent volume (L)	510	503 ± 1.95	4.38
${\theta }_6$	Body weight effect	1.30	1.37 ± 0.0363	27.0
$k_a$	Absorption rate constant	3.10	3.21 ± 0.0427	16.4
$ALA{G}_1$	Lag time of first-order absorption	0.25 (fix)	0.25 (fix)
Interindividual variability
ωCL/F	Interindividual variability of CL/F	0.223	0.223 ± 0.00155	7.06
ωV/F	Interindividual variability of V/F	0.826	0.829 ± 0.00699	8.57
Correlation coefficients
ρCL/F-V/F	Correlation coefficients between CL/F and V/F	0.191	0.190 ± 0.00349	18.7
Residual error
σadd, 1*	Additive error	0.0001 (fix)	0.0001 (fix)
σprop, 1*	Proportional error	0.0653	0.0657 ± 0.000754	11.7
σadd, 2*	Additive error	−2.48	−2.44 ± 0.0418	17.4
σadd, 3*	Additive error	2.86	2.85 ± 0.0021	0.75

^*Number refers to the hospital where data were collected (1: Seoul National University Hospital, 2: Inje University Busan Paik Hospital, 3: Chonnam National University Hospital).

CI, confidential interval; CL, clearance; F, bioavailability; V, volume of distribution; WT, body weight.