Table 2.
The significant dysregulated metabolites detected by LC-MS in HR-HPV infection groups (shared by HPV16 and HPV18). (P < 0.05).
| Metabolites | Compound ID | Class | HPV16(+) to HPV(-) | HPV18(+) to HPV(-) | ||
|---|---|---|---|---|---|---|
| Fold change | Pvalue | Fold change | Pvalue | |||
| Upregulated | ||||||
| (4S, 5S)-4,5-dihydroxy-2,6-dioxohexanoic acid | LMFA01050449 | Fatty acyls | 5.84 | 0.018 | 5.96 | 0.013 |
| Monomethyl phenylphosphonate | 87986 | Benzene and substituted derivatives | 4.78 | 0.012 | 4.82 | 0.011 |
| Glucoheptonic acid | 3365 | Unclassified | 4.28 | 0.010 | 4.30 | 0.007 |
| 2,3,4,5,6,7-Hexahydroxyheptanoic acid | HMDB0240292 | Organooxygen compounds | 3.43 | 0.007 | 3.95 | 0.008 |
| D-glucose | HMDB0000122 | Organooxygen compounds | 3.40 | 0.011 | 3.30 | 0.009 |
| 3alpha-androstanediol glucuronide | LMST05010004 | Sterol lipids | 2.37 | 0.014 | 2.17 | 0.001 |
| {3-[3-(3,4-dihydroxy-2-methoxyphenyl)prop-2-enoyl]phenyl}oxidanesulfonic acid | HMDB0126072 | Linear 1,3-diarylpropanoids | 1.83 | 0.016 | 2.08 | 0.013 |
| Dehydroepiandrosterone sulfate | HMDB0001032 | Steroids and steroid derivatives | 1.78 | 0.028 | 1.68 | 0.004 |
| 3,4,5-trihydroxy-6-{[(6E)-3-oxo-1,7-diphenylhepta-4,6-dien-1-yl]oxy}oxane-2-carboxylic acid | HMDB0133920 | Diarylheptanoids | 1.65 | 0.038 | 1.59 | 0.006 |
| LysoPC(P-16 : 0) | HMDB0010407 | Glycerophospholipids | 1.35 | 0.012 | 1.24 | 0.023 |
| PC(O-10 : 1(9E)/0 : 0) | LMGP01060027 | Glycerophospholipids | 1.31 | 0.009 | 1.35 | 0.011 |
| S-(9-deoxy-delta9,12-PGD2)-glutathione | HMDB0013058 | Carboxylic acids and derivatives | 1.18 | 0.041 | 1.24 | 0.005 |
| Downregulated | ||||||
| CerP(d18:1/18 : 0) | HMDB0010701 | Sphingolipids | 0.93 | 0.046 | 0.90 | 0.019 |
| Aspartyl-threonine | HMDB0028763 | Carboxylic acids and derivatives | 0.90 | 0.007 | 0.85 | 0.002 |
| Aspartyl-hydroxyproline | HMDB0028754 | Carboxylic acids and derivatives | 0.89 | 0.046 | 0.86 | 0.003 |
| 5-(4-hydroxyphenyl)pentanoic acid | HMDB0132270 | Fatty acyls | 0.84 | 0.003 | 0.71 | ≤0.001 |
| Threoninyl-glycine | HMDB0029061 | Carboxylic acids and derivatives | 0.82 | ≤0.001 | 0.73 | ≤0.001 |
| L-proline | HMDB0000162 | Carboxylic acids and derivatives | 0.81 | 0.014 | 0.82 | 0.041 |
| D-mannitol | 142 | Carboxylic acids and derivatives | 0.80 | 0.001 | 0.78 | 0.002 |
| 5-Hydroxylysine | HMDB0000450 | Carboxylic acids and derivatives | 0.76 | 0.007 | 0.69 | 0.001 |
| Xylobiose | HMDB0029894 | Carbohydrates and carbohydrate conjugates | 0.74 | 0.009 | 0.69 | 0.002 |
| Melibiitol | HMDB0006791 | Fatty acyls | 0.72 | 0.009 | 0.75 | 0.013 |
| 3,4,5-trihydroxy-6-{[8-(2-hydroxypropan-2-yl)-2-oxo-4-propyl-2H,8H,9H-furo[2,3-h]chromen-5-yl]oxy}oxane-2-carboxylic acid | HMDB0130128 | Coumarins and derivatives | 0.72 | ≤0.001 | 0.68 | ≤0.001 |
| 3,4,5-trihydroxy-6-{[4-methoxy-6-(3-oxoprop-1-en-1-yl)-2H-1,3-benzodioxol-5-yl]oxy}oxane-2-carboxylic acid | HMDB0128691 | Organooxygen compounds | 0.69 | 0.004 | 0.70 | 0.001 |