Table 3.
The dysregulated sphingolipids detected by LC-MS in HR-HPV infection groups (shared by HPV16 and HPV18).
| Metabolites | Subclass | HPV16(+) to HPV (-) | HPV18(+) to HPV (-) | ||
|---|---|---|---|---|---|
| Fold change | P value | Fold change | P value | ||
| SM(d18:1/16 : 0) | Phosphosphingolipids | 1.008647363 | 0.960836567 | 1.148556083 | 0.4425021 |
| PE-Cer(d14:1(4E)/21 : 0) | Phosphosphingolipids | 0.994218985 | 0.980618739 | 0.971725372 | 0.917332112 |
| PE-Cer(d15:1(4E)/20 : 0(2OH)) | Phosphosphingolipids | 1.026518539 | 0.825051177 | 0.763284427 | 0.030874248 |
| PE-Cer(d14:2(4E,6E)/23 : 0) | Phosphosphingolipids | 1.235600195 | 0.220069266 | 1.32418265 | 0.126840563 |
| LysoSM(d18 : 0) | Phosphosphingolipids | 1.15600553 | 0.38154612 | 1.063718638 | 0.664015868 |
| CerP(d18:1/8 : 0) | Ceramides | 0.989124633 | 0.298084598 | 0.97232671 | 0.582066007 |
| CerP(d18:1/18 : 0) | Phosphosphingolipids | 0.929021772 | 0.046445282 | 0.900844737 | 0.019284627 |
| PE-Cer(d14:1(4E)/22 : 0) | Phosphosphingolipids | 1.106493168 | 0.548411596 | 0.972063433 | 0.904319534 |
| PE-Cer(d15:1(4E)/20 : 0) | Phosphosphingolipids | 1.024621854 | 0.891435105 | 0.860938383 | 0.541710157 |
| Sphingosine 1-phosphate | Phosphosphingolipids | 1.278071996 | 0.025880223 | 1.2270139 | 0.077561076 |
| Fumonisin C4 | Sphingoid bases | 0.961671783 | 0.698445871 | 0.870575355 | 0.149158739 |
| Sphinganine 1-phosphate | Phosphosphingolipids | 1.864757476 | 0.000578872 | 1.613256039 | 0.03946171 |
| GlcCer(d15:1/18 : 0) | Neutral glycosphingolipids | 1.013763546 | 0.910410253 | 1.042723407 | 0.804255575 |
| SM(d18 : 0/16 : 0) | Phosphosphingolipids | 0.994611391 | 0.965697302 | 1.01082142 | 0.946834371 |
| Araliacerebroside | Glycosphingolipids | 0.772097545 | 0.10844525 | 0.758894277 | 0.128499741 |
| Scyphostatin A | Sphingoid bases | 1.253647394 | 0.241779922 | 1.453491412 | 0.080949335 |
| PI-Cer(t18 : 0/18:0(2OH)) | Phosphosphingolipids | 0.997887814 | 0.983753132 | 1.073429615 | 0.479910841 |
| GlcCer(t18:1(8Z)/20 : 0(2OH[S])) | Neutral glycosphingolipids | 1.027065099 | 0.728185535 | 0.872833743 | 0.219830931 |
| GlcCer(t18:1(8Z)/16 : 0(2OH[S])) | Neutral glycosphingolipids | 1.025729401 | 0.879659091 | 0.89589231 | 0.646495931 |
| SM(d18:2/18:1) | Phosphosphingolipids | 1.078895147 | 0.438313999 | 1.013775708 | 0.903558948 |
| GlcCer(d18:0/26 : 0) | Neutral glycosphingolipids | 0.861561787 | 0.057511869 | 0.814073191 | 0.00864914 |
| Leucettamol A | Sphingoid bases | 1.216677861 | 0.060461464 | 1.395757442 | 0.000331627 |
| PE-Cer(d14:1(4E)/24 : 0(2OH)) | Phosphosphingolipids | 1.221487438 | 0.31415695 | 1.144323565 | 0.603339326 |
| SM(d18:1/18:1(11Z)) | Phosphosphingolipids | 1.202363713 | 0.328745941 | 1.308235935 | 0.177725258 |