Fig. 2.

The association of polygenic risk score for hearing performance with cognitive function and brain structure. The polygenic risk score (PRS) for hearing performance was associated with cognitive function, grey matter volume, and white matter microstructure integrity in the multiple linear regression models with the covariates including age, sex, body mass index, Townsend deprivation index, education qualification, smoking status, drinking status, and imaging scanning sites (only for brain imaging) in the UK Biobank. Abbreviations: PRS, polygenic risk scores; “∗” P < 0.05; “∗∗” P < 0.01; “∗∗∗” P < 0.005; “∗∗∗∗” P < 0.001.