Fig. 2.

The potential mechanism diagrams of regulatory mechanisms involving FMT on bone metabolism. Based on the gut–bone axis, the underlying mechanisms of FMT mainly lie in reconstruction of normal intestinal micro-ecology, which could participate in the regulation of bone metabolism by repairing intestinal mucosal barrier, regulating immune response, improving intestinal permeability, correcting gut microbiota disorder, and reversing intestinal metabolites imbalance. FMT fecal microbiota transplantation, OB osteoblast, OC osteoclast